Distribution of pathogenic bacteria in women with cystitis in community and treatment strategies

Abstract

Objective To investigate the bacterial distribution characteristics of female cystitis patients in the community and evaluate the effect of using different antimicrobial agents. Methods Female patients with cystitis from January 2015 to January 2017 in our hospital were selected to receive clean midstream bacteriological culture before treatment to analyze the distribution characteristics of pathogens, and were randomly divided into fosfomycin treatment group and routine treatment. In the fosfomycin-treated group, the fosfomycin tromethamine was scattered, and in the conventional treatment group, according to the conventional anti-infective drugs, the curative effect, the detection index, and the concentration of RhoA/Rho kinase were compared between the two groups after the third and seventh days after taking the drugs. Results The urine cultures of 157 patients were all positive. A total of 144 gram-negative bacteria (91.7%) were isolated with Escherichia coli and 13 were gram-positive (8.3%). After 3 days of treatment, the efficacy of the fosfomycin-treated group was better than that of the conventional treatment group (P 0.05), and the concentration of RhoA/Rho kinase decreased after treatment (P<0.05). In addition to the total amount of urinary excretion in the fosfomycin-treated group, other testing indicators and RhoA/Rho kinase concentrations were lower than those in the conventional treatment group (P<0.05). The Chaol, Simpson index and the relative abundance of all types of bacteria of the fosfomycin-treated group was significantly lower than that of the conventional treatment group (P<0.05). Conclusions The main pathogen of female cystitis in the community is Gram-negative bacteria mainly composed of Escherichia coli, which can be used as the first-line drug for the treatment of female cystitis. Key words: Cystitis; Femininity; Opportunistic Infections