Abstract
The distribution of spontaneous cell-mediated cytotoxicity (Natural Killer Cell Activity—NK-Activity) was studied in peripheral blood from normal adult blood donors and in cord blood. The NK activity was also measured in the lymphoid organs: thymus, lymph nodes and spleen and the effect of human interferon preparation on the NK activity was measured. It is demonstrated that the NK activity in peripheral blood ranges from 25–80% specific cytotoxicity when measured on the erythroleukemic cell line K 562, while 30% of newborns do not have significant NK activity. The NK activity can be substantially enhanced in peripheral blood and in cord blood, slightly increased in spleen cells but not affected in thymus and lymph nodes following in vitro treatment with human interferon preparation. The study demonstrates that there are qualitative differences in the distribution of NK cells and their precursors in the different lymphoid organs.
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