Abstract

PurposeTo explore the distribution of node spread from lymphoepithelial-like carcinoma (LELC) of the parotid gland based on the 2013 updated guidelines for neck node levels.Results42 (58.3%) cases had metastatic nodes, all were localized at the ipsilateral neck. The detailed distribution was: level Ia 0, level Ib 6(14.3%), level II 34 (80.1%), level III 16 (38.1%), level IV 9 (21.4%), level V 7 (16.7%), level VI 0, level VII 0, level VIII 37 (88.1%), level IX 0, level Xa 2 (4.8%), and level Xb 0. Lymphadenopathy in level Ib, V and Xa was always accompanied with level II or level VIII nodal metastasis. No statistical significance was found in the incidence of nodal involvement between T1-2 and T3-4 tumors (57.4% versus 61.1%, p = 0.78).MethodsWe retrospectively reviewed the surgical and imaging documents of 72 cases of LELC from the parotid gland between January 2004 and November 2015. All patients received contrast enhanced computed tomography (CT) or magnetic resonance imaging (MRI). Parotid metastasis from nasopharyngeal cancer (NPC) was excluded. Nodal status and distribution was evaluated by both pathologic reports and imaging studies.ConclusionsThis is the first description of topography of cervical nodal metastases from LELC of the parotid gland. Incidence of nodal involvement is high. Nodes at ipsilateral level VIII and II were most frequently involved, followed by level III, IV, V and Ib. Nodes in level Ia, VI and level VII were rarely seen.

Highlights

  • Lymphoepithelial-like carcinoma (LELC) of the salivary gland is a rare malignancy

  • Nodal status and distribution was evaluated by both pathologic reports and imaging studies. This is the first description of topography of cervical nodal metastases from LELC of the parotid gland

  • The World Health Organization (WHO) has defined it as ‘‘a poorly differentiated squamous cell carcinoma or histologically undifferentiated carcinoma accompanied by a prominent reactive lymphoplasmacytic infiltrate, morphologically similar to undifferentiated nasopharyngeal carcinoma (NPC)’’ [2]

Read more

Summary

Introduction

Lymphoepithelial-like carcinoma (LELC) of the salivary gland is a rare malignancy. It was first described by Hilderman et al in 1962 [1]. The World Health Organization (WHO) has defined it as ‘‘a poorly differentiated squamous cell carcinoma or histologically undifferentiated carcinoma accompanied by a prominent reactive lymphoplasmacytic infiltrate, morphologically similar to undifferentiated nasopharyngeal carcinoma (NPC)’’ [2]. LELC is separated from NPC by its location and clinical outcome. LELC has been diagnosed in numerous organs of the head and neck region. The majority (about 80%) is located in the parotid gland [3, 4]

Methods
Results
Conclusion
Full Text
Published version (Free)

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call