Abstract
To examine drug penetration into vestibular organ, the distribution of kanamycin-sulfate (KM) in the peripheral organ was examined immuno-histologically. Intravenously administered KM easily reaches to the sensory epithelial layer of the crista ampullaris and macula statica in 3090min, although it has been said that the blood-laryrinth-barrier inhibits the penetration of drugs. The distribution of KM is similar to the pattern of degeneration of the vestibular organ induced by aminoglycosides. After 2448hr, KM is still present in the vestibular organ, not in the sensory epithelium but in the sub-epithelial tissue.
Full Text 
Sign-in/Register to access full text options
Sign-in/Register to access full text options 
Paper version not known
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
