Abstract
In this paper, we propose and investigate distribution of intravascular and extravascular extracellular volume fractions (DIEEF) as a noninvasive biomarker for neovascularization assessment by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). A generalized two-compartment exchange model (G2CXM) that uniformly includes the Patlak model, Tofts model, extended Tofts model, and recent two-compartment exchange model as special instances is first presented. Based on the total area under curve of the G2CXM a method of DIEEF estimation without knowing the artery input function is proposed. The mean square error of DIEEF estimate in the presence of noise and with incomplete DCE-MRI data is analyzed. Simulation results demonstrate that DIEEF estimate is accurate when signal to noise ratio is only 5 dB in both cases of tracer infusion and bolus injection, and slightly favors the bolus injection. Tested on a model of atherosclerotic rabbits, the DIEEF of aorta plaques is positively correlated with the histological neovessel count with correlation coefficient of 0.940 and P = 0.017, and outperforms six semiquantitative parameters in the literature. DIEEF might be useful as a biomarker for noninvasive neovascularization assessment by DCE-MRI.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
