Distribution of Indian population-specific transporter SNPs among Asians and their physiological consequences

Abstract

Membrane transporters are the very crucial protein which transport endo and exogenous compound across the organelle and cellular membrane. These transportation make feasible various biological processes ranging from cell signaling to drug transportation. The two major human protein families of membrane transporter are ABC and SLC which transport molecules using active energy and cellular gradient respectively. Alteration of these protein structures can modulate the molecule transportation rate thus affect their routine physiological functions. Single nucleotide polymorphism (SNP) is one of the widely distributed and well-studied genomic-variant which reported to affect these membrane transporters at the genomic level and alter host physiology and in fact some time cause pathophysiology as well. Presence of these associated-SNPs are very crucial, thus their consideration in various clinical purposes make a significant contribution. Various genomic projects and SNP mining made it clear that most of these SNPs are not global in their occurrence, their alleles are population-specific, and thus their population-specific mining and association studies are very essential before their use. The current study aims for analysis of distribution pattern of Indian population-specific transporter SNPs among the Asian population and their association with the biological processes. The resulted distribution patterns will be useful for the selection of marker SNPs for various pathophysiology's and clinical studies.