Distribution of HLA antigens in patients with Ewing's sarcoma.

Abstract

Thirty-eight unrelated Caucasian patients with Ewing's sarcoma were typed for HLA-A and B locus antigens. Although no significant differences in the distribution of these antigens were found in comparison with local controls, a trend towards increases in LHA-B8 and Aw19 complex antigens was noted. Although American blacks are only rarely affected by this tumor, the two black patients we typed both had the HLA-Aw19 complex antigen, Aw31. This suggests that a disease susceptibility factor may be in linkage disequilibrium with HLA-Aw19 complex HLA antigens.