Abstract

Inherited structural differences in human immunoglobulins are referred to as allotypes or genetic markers. So far, genetic markers have been found for the IgG heavy (H) chain (Gm), the IgA chain (Am), the IgE chain (Em) described recently by van Loghem et aI. (1984), and the kappa type light chain (Km) common to all classes of immunoglobulins. The Gm system provides genetic markers which are unique in studies of human genetics, particularly in the characterization of different populations and in studies of gene flow and genetic drift determined by the presence of either a unique haplotype in a particular race or by differences in the frequencies of the same haplotypes in a given ethnic group.

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