Abstract
The chronic effects of low doses of cadmium on the distribution of soluble and filament forms of glial fibrillary acidic protein (GFAP) and their polypeptide fragments in different parts of the rat brain were investigated. Obtained results showed dose-dependent effect of cadmium on the soluble form of GFAP and more pronounced effect on the filament form and composition of the polypeptide fragments of the protein in the rat brain. Prolonged intoxication by cadmium ions in a dose of 1.0 μg/kg of body weight induced a significant decrease in soluble GFAP and an increase in the filament form in the rat brain, pointing to the development of reactive astrogliosis and the risk of neurodegeneration.
Highlights
From all known metals, cadmium (Cd) has been identified to be one of the most harmful to mammals especially humans [1, 2]
Cells of various organs including the kidney, liver, gonads, bones, spleen, brain and red blood cells are susceptible to cadmium exposure
These results indicate that CdCl2 may significantly affect the ratio of neurons and glial cells during the development of the human spinal cord and are potentially involved in the etiopathogenesis of neurodegenerative diseases
Summary
Cadmium (Cd) has been identified to be one of the most harmful to mammals especially humans [1, 2]. From the point of view of the marker concept, it is considered that the response of astrocytes to the effect of the stress-factors is nonspecific and the intensity of GFAP biosynthesis depends on the factors’ dose and the exposure time rather than their nature. In this regard, comparative characteristics of negative factors of various origins, as well as their cumulative effect on GFAP metabolism are current points of interest. The aim of the study was to investigate the chronic effects of low doses of cadmium on the distribution of soluble and filament forms of glial fibrillary acidic protein and its polypeptide fragments in different parts of the rat brain
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