Abstract
Contrasting results have been reported on the effect of steroid hormones on the interaction between ribosomes and endoplasmic reticulum in rat liver. Exposure to high gravitational forces for a long time was found necessary to obtain a constant ratio of free to membrane-bound ribosomes from the post-nuclear supernatant. Using these isolation conditions, rat liver from fasted controls and from fasted, adrenalectomized rats contain both about 45% membranebound ribosomes. Addition of corticosterone to the livers from adrenalectomized rats did not increase the pool of bound ribosomes more than in the control livers; 55% was found in both. Corticosterone had therefore no effect on the pool sizes of free and membrane-bound ribosomes in perfused rat livers.
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