Abstract
Aims: Prostaglandins produced by the action of cyclooxygenases (COX) are important mediators of systemic vasodilatation and inflammation in liver cirrhosis. The aim of this study was to investigate the distribution...
Highlights
The expression of COX-2 was greatly upregulated in cirrhotic liver, where it was localised in inflammatory cells infiltrating the liver, mainly mononuclear-like cells, vascular endothelial lining cells, Kupffer cells seen in sinusoidal spaces, and the epithelial lining of bile ducts
COX-2 was not seen in normal liver, but showed de novo synthesis and pronounced upregulation in liver cirrhosis
This induction of COX-2 may be the result of active inflammation in cirrhosis, secondary to hepatitis
Summary
Results: COX-2 was absent from normal liver but was highly expressed in cirrhosis, mainly in the inflammatory, sinusoidal, vascular endothelial, and biliary epithelial cells.
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