Abstract
This study focuses on the identification and the distribution of Colistin resistance genes among Gram-negative bacteria isolated from clinical samples at the National Ribat Teaching hospital, in Khartoum, Sudan.
Highlights
Antibiotics resistance has become a major concern among Gram-negative bacterial infections because of the unavailability of alternative treatment options
This study focuses on the identification and the distribution of Colistin resistance genes among Gram-negative bacteria isolated from clinical samples at the National Ribat Teaching hospital, in Khartoum, Sudan
Out of 165 different clinical samples collected from patients suffering from different infections, 165 Gram-negative bacterial strains were obtained as following, E. coli (53/32.1%), K. pneumoniae (73/44.2%), P. aeruginosa (33/20%), Colistin-resistant (6/3.6%), and C. freundii (2/1.2%), (Table 2)
Summary
Antibiotics resistance has become a major concern among Gram-negative bacterial infections because of the unavailability of alternative treatment options. The antibiotic resistance phenomenon is emerged due to antibiotics overuse and bacterial evolution [1]. Colistin is a cationic polypeptide-based antibiotic, known as polymxin E, it’s considered the reserve antibiotics against the multidrug resistance (MDR) infections caused by Gramnegative bacterial pathogens such as Enterobacteriaceae [2,3]. There is an increased in the resistance of bacteria against several commonly used antibiotics and the limitation in discovery of a new ones had led the Colistin as a valuable drug of choice for many MDR strains [5,6,7]. MDR, extensively drug-resistant (XDR), and pan-drug-resistant (PDR) strains of E. coli and other Enterobacteriaceae strains were detected worldwide, and they were harboring multiple resistance mechanisms [8,9,10]
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