Abstract
Background:Salmonella entericahas become increasingly resistant to antimicrobial agents, partly as a result of genes carried by integrons.Objective:The aim of the present study was to investigate the prevalence of class 1 and 2 integrons and resistance to antimicrobial agents in clinical isolates ofS. enterica.Methods:This study included allSalmonellaisolates, recovered from patients with salmonellosis, admitted to Medical Children Hospital, Tehran, Iran during 2015-2016. Bacterial isolates were identified using standard biochemical and agglutination tests. Antimicrobial susceptibility testing was performed according to the Clinical and Laboratory Standards Institute guidelines. The presence of class 1 and 2 integrons was investigated by Polymerase Chain Reaction (PCR) assay, using specific primers.Results:A total of 138Salmonellastrains were isolated and included in this study. Integrons were detected in 45 (32%) isolates. Class 1 and 2 integrons were detected in 24 (17.3%) and 21 (15.2%) isolates, respectively. All integron-positive isolates showed multidrug-resistant phenotypes. Resistance to more than three antimicrobial agents was observed in integron-positive isolates.Conclusions:Our findings showed that integrons were widely distributed amongS. entericaisolates in Tehran. Class 1 integrons are more prevalent than class 2 integrons inSalmonellaisolates, and there is an association with MDR patterns. Therefore, these integrons are more likely to be involved in the distribution of resistant phenotypes inSalmonellastrains.
Highlights
Gastroenteritis and diarrheal diseases are among the most important health problems worldwide, especially in developing countries [1]
Our findings showed that integrons were widely distributed among S. enterica isolates in Tehran
Class 1 integrons are more prevalent than class 2 integrons in Salmonella isolates, and there is an association with MDR patterns
Summary
Gastroenteritis and diarrheal diseases are among the most important health problems worldwide, especially in developing countries [1]. Salmonella remains one of the most common causes of acute gastroenteritis and food-borne infections. There are many mechanisms of antibiotic resistance through which bacteria exhibit resistance to antibiotics. Acquisition of genetic elements is one of the major mechanisms, which frequently occurs in both Gram-positive and Gram-. The Open Microbiology Journal, 2019, Volume 13 Primers Int Int. Salmonella enterica has become increasingly resistant to antimicrobial agents, partly as a result of genes carried by integrons
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
