Abstract
BackgroundTo investigate distributions of cervical lesions and factors associated with the severity of the cervical lesions in high-risk HPV (hr-HPV) positive women with atypical squamous cells of undetermined significance (ASC-US) cytology.MethodsClinical information of 250,000 women who underwent HPV and cytological test was collected from January 2012 to January 2019. The association between the severity of the cervical lesions and hr-HPV genotypes, hr-HPV viral load, and ages, were analyzed in hr-HPV-positive/ASC-US women.Results3459 hr-HPV-positive/ASC-US women were enrolled in this study. Overall, 43.51% of women with ASC-US had normal histological results, 34.35% had high-grade squamous intraepithelial lesion (HSIL), and 1.30% had cervical cancer. The rate of HSIL or worse (HSIL+) in women with single HPV16 infection (63.09%) was the highest, followed by HPV33 (57.50%), HPV51 (36.11%), HPV58 (36.11%), HPV52 (28.28%), HPV18 (26.37%), HPV66 (19.35%), HPV39 (18.92%), HPV53 (15.00%), and HPV56 (8.51%). Detection rate of HSIL+ in low, intermediate and high viral-load groups were 15.87% (n = 30), 34.91% (n = 74) and 40.68% (n = 214) (Cochran-Armitage Trend test χ2 = 35.03, p < 0.0001). Compared with the 51–60-year-old group (21.65%), the women in ≤ 30 (40.52%), 31–40 (39.67%), and 41–50 (34.22%) year-old groups had significantly higher risk of HSIL+. The women in ≤ 51–60 (2.68%) and > 60 (3.41%) year-old groups were at increased risk for cervical cancer, compared with the ≤ 30-year-old group (0.61%).ConclusionsASC-US women with HPV 16/18/33/51/52/58 single infection and multiple infections, as well as high HPV viral loads, have high risk of HSIL+.
Highlights
To investigate distributions of cervical lesions and factors associated with the severity of the cervical lesions in high-risk HPV positive women with atypical squamous cells of undetermined significance (ASC-US) cytology
Full list of author information is available at the end of the article high-risk human papillomavirus infection is main cause of cervical lesions [3, 4]
This study aimed to investigate the distribution of hrHPV genotypes, the association between the severity of the cervical lesions and high-risk HPV (hr-HPV) viral loads, and agestratified prevalence of high-grade squamous intraepithelial lesion (HSIL) and cervical cancer, by analyzing of clinical information of HPV-positive/ASC-US women in
Summary
To investigate distributions of cervical lesions and factors associated with the severity of the cervical lesions in high-risk HPV (hr-HPV) positive women with atypical squamous cells of undetermined significance (ASC-US) cytology. Full list of author information is available at the end of the article high-risk human papillomavirus (hr-HPV) infection is main cause of cervical lesions [3, 4]. HPV16 causes 60% of cancers and 50% of precancerous lesions, HPV56 rarely causes cancer [6,7,8]. It takes 20–30 years from precancerous lesions to cervical cancer, and such long period provides doctors possibilities for intervention [9, 10]. Cervical cytology test and HPV test are the most common methods for cervical cancer screening
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
