Abstract
Sampson's theory of retrograde menstruation remains the leading hypothesis for the pathogenesis of endometriosis. While most reproductive age women experience retrograde menstruation, the prevalence of endometriosis is only 7-10%. We hypothesize that endometriosis results from defects in the stem cell niche, causing more shedding of endometrial progenitors. Recently our group identified CD44 as one marker for isolation of endometrial epithelial progenitors (Stem Cells 2012, 4:808-22). The purpose of this study was to assess if uterine epithelial progenitor cells marked by CD44 are present at increased frequencies in ectopic endometrial implants.
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