Abstract
Summary Adult guinea pigs were loaded with 2 ml of 50% C14-DMSO in saline and sacrificed at predetermined intervals. Liquid scintillation assay of tissues and body fluids indicated presence of C14-DMSO in all assayed tissues and fluids. In blood serum DMSO was not bound to serum proteins. Autoradiographic results indicated over-whelming tendency of C14-DMSO to be confined to interstitial spaces. Localization of C14-DMSO activity sites along cell membranes of various tissues and organs is interpreted in terms of relative impermeability of cell membranes to pharmacological doses of DMSO solvated in body fluids.
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