Abstract
SEROLOGICAL reagents have been used to identify allelic antigenic determinants of the peptide chains of immunoglobulins1. Several allotypic determinants of the heavy chains of human immunoglobulins have been identified2 and their distribution in human populations3 has been investigated. Only a few allotypic determinants of the K-type light chain of human immunoglobulins have been identified2 and one of these has been correlated with an amino-acid interchange in the invariable half of these peptide chains4–6. No homologous serological reagent has been available for the study of the L-type light chain.
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