Abstract
Qualitative and quantitative distribution of acid-soluble nucleotides in muscle from mice with dystrophia muscularis was compared to normal mouse muscle using filter paper chromatography followed by elution and U.V. spectrophotometry. Qualitatively, no apparent differences were found in the number and types of nucleotides present in both tissues. Similar results were obtained using radioautography with P32. Significant amounts of AMP, ADP, ATP, DPN, GTP, GDP were found, while smaller amounts of components tentatively identified as UDP, UTP, CTP and IDP were also observed. The concentrations of AMP, GTP (including UTP), and GDP (including UDP, CTP, and IDP) were significantly higher in the hind limb muscles of dystrophic mice than those obtained for normal mouse muscles, while for ATP the reverse was found. Slight or no significant differences were found in the acid-soluble nucleotides of animals with experimentally induced atrophy of the hind leg when compared to the normal group, while histologically there was a significant decrease of the individual muscle fiber diameter in the atrophic muscle.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
