Abstract

Little is known about the specific mechanism of human toxicity or the long term health effects of TCDD exposure. Acute effects such as chloracne may appear and disappear before more long-term effects manifest themselves, such as possible immune system suppression. The distribution of TCDD in the human body has not been documented. Due to its lipophilic nature, however, it has been quantitated from extracts of adipose tissue, breast milk, and, more recently, in serum. The transport and eventual equilibration of most xenobiotic substances proceeds from the blood into tissues. Investigators have studied the partitioning of TCDD among lipoprotein species, but the potential associations with other serum proteins and red blood cells have not been thoroughly documented. In developing and documenting a method for quantifying TCDD in serum samples, the authors needed to determine its distribution and availability for extraction in the blood. They sought to determine the partitioning of TCDD (when added in vitro to whole blood), among the cellular, serum protein, and lipoprotein components.

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