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Abstract
The distribution of heated radioiodinated human serum albumin (IHSA) was investigated in the rat.Increase in duration of heat treatment at 70 °C resulted in increased liver uptake. The fraction of the injected dose remaining in the blood decreased with increase in duration of heat treatment.Similarly, increase in temperature of heating from 65 °C to 75 °C resulted in increased liver uptake. The fraction of the injected dose remaining in the blood decreased with increase in temperature of heating.The liver:blood radioactivity concentration ratios provide an index of the degree of heat denaturation of iodinated human serum albumin preparations.
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