Abstract
BackgroundLower respiratory tract infection (LRTI) is one of the leading cause of death in children under 5 years old around the world between 1980 and 2016. Distinguishing between viral and bacterial infection is challenging when children suffered from LRTI in the absence of pathogen detection. The aim of our study is to analyze the difference of serum β2-microglobulin (β2-MG) between viral LRTI and bacterial LRTI in children.MethodsThis retrospective study included children with LRTI caused by a single pathogen from Yancheng Third People’s Hospital, Yancheng, China, between January 1, 2016 and December 31, 2019. Participants were divided into the younger group (1 year old ≤ age < 3 years old) and the older group (3 years old ≤ age < 5 years old) for subgroup analysis.ResultsA total of 475 children with LRTI caused by common respiratory pathogens were identified. In the younger group as well as the older group, the serum level of β2-MG in respiratory syncytial virus, influenza A virus and influenza B virus groups were significantly increased compared to that in the Mycoplasma pneumoniae group. Compared with Streptococcus pneumoniae infection group, the serum β2-MG level of respiratory syncytial virus, influenza A virus and influenza B virus groups were significantly higher in children between 1 and 3 years old.ConclusionsThe serum β2-MG may distinguish viral infection from bacterial infection in children with LRTI.
Highlights
Lower respiratory tract infection (LRTI) is a common disease in children, and it brings economic burden to families
Is there a better biomarker to identify viral infection in LRTI? We retrospectively studied the serum levels of β2-MG in patients with LRTI caused by respiratory syncytial virus, influenza A virus, influenza B virus M. pneumonia and Streptococcus pneumonia
In the younger group (1 year old ≤ age < 3 years old), it is mainly 78.6% of children affected by respiratory syncytial virus, 52.1% of children affected by influenza A virus and 78.6% of children affected by Streptococcus pneumonia
Summary
Lower respiratory tract infection (LRTI) is a common disease in children, and it brings economic burden to families. Distribution characteristics of serum β2-microglobulin between viral and bacterial lower respiratory tract infections: a retrospective study. Lower respiratory tract infection (LRTI) is one of the leading cause of death in children under 5 years old around the world between 1980 and 2016. Distinguishing between viral and bacterial infection is challenging when children suffered from LRTI in the absence of pathogen detection. In the younger group as well as the older group, the serum level of β2MG in respiratory syncytial virus, influenza A virus and influenza B virus groups were significantly increased compared to that in the Mycoplasma pneumoniae group. Compared with Streptococcus pneumoniae infection group, the serum β2-MG level of respiratory syncytial virus, influenza A virus and influenza B virus groups were significantly higher in children between 1 and 3 years old. Conclusions: The serum β2-MG may distinguish viral infection from bacterial infection in children with LRTI
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