Abstract
Distribution and translocation of engineered nanomaterials (ENMs) is one of the crucial cellular contributors for the toxicity induction of ENMs. After exposure, the primary targeted organs of ENMs can be defined as the intestine and the epidermis, and the secondary targeted organs of ENMs contain at least the reproductive organs, such as the gonad and the spermatheca, and the neurons in nematodes. So far, the normally considered primary targeted organ for ENMs is the intestine in nematodes. In this chapter, we first introduce the techniques for the analysis on distribution and translocation of ENMs. Moreover, the distribution and translocation of different ENMs in the primary or the secondary targeted organs, as well as the patterns of transgenerational translocation of ENMs, and the underlying cellular, molecular, and chemical metabolisms for distribution and translocation of ENMs are systematically introduced.
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