Abstract
Objective To detect safety,slow-release characters and targeting effects of two kinds of gemcitabine(GEM)-loaded bovine serum albumin nanospheres(mean particle diameters were 110 and 406 nm respectively)through tissue distribution in SD rats.Methods Thirty male SD rates were divided into 3 groups:(1)GEM group(n = 10);(2)110 nm GEM nanospheres group(n = 10);(3)406 nm GEM nanospheres group(n = 10).Pure GEM was used as the model drug,and SD rats as experimental model animal.The concentrations of GEM in blood plasma and various organs of SD rats were dynamically detected by high performance liquid chromatography(HPLC).Results Blood plasma GEM-time curve in GEM group was higher than the other two groups(P ＜ 0.05).The concentrations of GEM in targeting organs,including pancreas(155.59 μg/g),liver(43.57 μg/g)and spleen(35.27 μg/g),were significantly higher in 406 nm nanospheres group than the other two groups 6 h after administration,but those of GEM in heart(116.26 μg/g),lung(8.32 μg/g),kidney(92.10 μg/g),and muscles(81.58 μg/g)were similar to the other 2 groups(P ＞0.05).Conclusion 406 nm GEM-loaded serum albumin nanospheres had excellent targeting effect,slow-release character and safety,and could be applied to the treatment of pancreatic cancer by regional intra-arterial infusion chemotherapy. Key words: Gemcitabine; Nanoparticle; Albumin; Pancreatic carcinoma
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