Abstract
The metabolism of ${}^{243,244}{\rm Cm}$ citrate has been studied in six adult female baboons for periods ranging up to 26 months after intravenous injection. In vivo measurements with γ-ray scintillation detectors were used to estimate parameters of deposition and retention of ${}^{243,244}{\rm Cm}$ for the total body and specific organ sites. In addition, ${}^{243,244}{\rm Cm}$ was measured in urine, feces, blood, and biopsy samples of liver. Curium-243,244 leaves the blood rapidly, and 0.7% of the injected dose (ID) is present in the blood 24 hr after injection. The primary sites of early deposition are skeleton (≃60% ID) and liver (≃20% ID). The retention of ${}^{243,244}{\rm Cm}$ in bone is protracted with a half-time of several years, while that in liver is about 40 days. Approximately 7% of the injected dose is excreted in the urine during the first 24 hr. Curium-243,244 eliminated from the liver appears to be excreted predominantly in feces as is the case for241 Am.
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