Abstract
Previous work has shown that a meningoencephalom yet it is, sometimes with foci of demyelinization, may occur in monkeys, guinea pigs, and rabbits 2 to 9 weeks following the subcutaneous or intramuscular injection of brain tissue mixed with acid-fast bacilli in a water-in-oil emulsion.1-6 In contirmatory work in this laboratory an ascending paralysis has developed in slightly niore than half of some 90 guinea pigs following the single subcutaneous injection of one cc of siniilar emulsions containing guinea pig, rabbit. human. or beef brain suspended 1:20 in 0.9:; saline. The illness usually began 15 to 31 days after injection. although it was delayed as long as 74 days in one case; the aniinals usually died within 10 days, although 3ome recovered and others remained paralyztd ior one to 2 months. Histological examination.; oi brain and qpinal cord removed from about 30 paralyzed guinea pigs in every case rewiled a patchy or diffuse perinscular inflammation. Predominantly lymphocytic in the leptonieninges ...
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
