Abstract
Mitochondria are important organelles involved in energy production, carbohydrate metabolism, heme biosynthesis and the urea cycle. In the present study the distribution patterns of eleven elements in mitochondrial compartments of normal human liver specimens were studied by applying the chemical separation techniques and differential centrifugation combined with element-specific methods of instrumental neutron activation analysis (INAA) and hydrid-generation atomic fluorescence spectrometry (HG-AFS). The results showed that the concentrations were higher of Ca, Co and Zn in the matrix and Ba, Cr, Fe, Sb, Sc, and Th in the outer membrane, whereas the highest concentration of Rb was in the intermembrane space. Interestingly, the lowest concentrations of all the eleven elements, except Se, were found in the inner membrane.
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