Abstract
Background: Gingival enlargement detected as a result of pathological changes or by induction of drugs such as Phenytoin. Changes in distribution of macromolecules of glycogen, proteoglycan and glycoprotein in gingival enlargement were observed by histochemical method. The aim of the study was to illustrate the localization and distribution of ground substance in an inflammatory and Phenytoin induced gingival enlargement, using histochemical methods. Materials and Methods: Twenty two individuals, ten with inflammatory gingival enlargement, other ten with Phenytoin induced gingival enlargement and two healthy person extraction of impacted 3rd molar as control .The specimens were stained with periodic acid Schiff reagent (PAS). Results: In the inflammatory gingival enlargement there is an increase in carbohydrate material production concern to epithelial layer, basement membrane and underneath connective tissue showing reddish purple stain with PAS reaction, while Phenytoin induced gingival enlargement showed increment in epithelial layer only. Conclusion: Histochemical method by PAS stain used to show difference in distribution of carbohydrate group in gingival specimens of inflammatory and Phenytoin induced gingival enlargement.
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