Abstract
Radioimmunoassay of 71 normal adult human sera gave a mean properdin concentration of 19.3 ± 5.4 μg/ml. Similar values were found in sera from patients wit ssickle cell anemia and in maternal serum at the time of full-term delivery. A limited ontogenetic study revealed that the concentration of properdin in fetal serum increased progressively during gestation, reaching one-half to two-thirds of adult levels at parturition and full adult levels about 1 yr later. Properdin was not present in significant concentrations in amniotic fluid, milk, colostrum, parotid saliva, nasal washings, sweat, gastric juice, bile, urine, seminal fluid, and cerebrospinal fluid indicating the absence of an intact properdin pathway in these normal fluids.
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