Abstract
Rats were given a single oral dose of 44mg of polychlorinated quaterphenyls (PCQ) per rat, or repeated oral doses of 1.26mg of PCQ/rat/day for 10 days. After a single oral dose of 44mg/rat, PCQ was excreted into the feces throughout the experimental period. The cumulative amount of PCQ in the feces in 6 days reached 97% of the total dose. PCQ, however, were hardly excreted into the urine. Six days after administration, approximately 2.3% of the total dose was present in the rat tissues. The liver contained the highest concentration, and approximately 50% of PCQ loaded in the whole body was found in the liver.Following repeated oral doses of 1.26mg/rat/day for 10 days, the PCQ concentration 1 day after the final administration of PCQ was highest (34.1ppm) in the liver, followed by the adipose tissue (5.1ppm)>kidney>lung>heart>spleen>thymus>brain. After 50 days, adipose tissues contained the highest concentration (1.3ppm), followed by the liver (1.1ppm). The blood showed the lowest concentration (0.04ppm). The biological halflives of PCQ in rat tissues ranged from 14.1 days in liver to 41.3 days in adipose tissue.The components of the residual PCQ differed between adipose tissue and liver. That is to say, more highly chlorinated PCQ was observed in the liver compared with that in the adipose tissue.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi)
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
