Abstract
Pharmacokinetic studies are important tools in improving the dosage regimens for antibiotics curently in use. In this study elimination half-life, apparent volume of distribution and total clearance of oxolinic acid (OA) were estimated after a single intravascular injection of OA in rainbow trout kept in freshwater and in seawater at 8.5°C. The drug was given as a rapid injection through a cannula into the dorsal aorta. Repeated blood samples were taken via the cannula and serum was analysed by reversed-phase high-performance liquid chromatography. The terminal elimination half-life for OA in rainbow trout was estimated to be 52.6 h in freshwater ( t 1 2 ,β ) and 29.1 h in seawater ( t 1 2 ,τ ). This considerable difference in elimination half-lives was mainly due to the increase in total clearance; total clearance (Cl T) values were 1.2 and 2.0 l kg −1 24 h −1. The apparent volume of distribution ( V d(ss)) was estimated to be 2.9 and 2.6 l kg −1 in freshwater and seawater, respectively.
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