Abstract

Objective To investigate the distribution and drug resistance of pathogens in urine cultures of patients with long-term indwelling catheterization. Methods Urine samples of 201 patients with long-term indwelling catheterization were collected in 2016. All 362 strains of pathogens were isolated, and the pathogens were identified by VITEK2 and related reagents, and the concurrent drug sensitivity tests were done. Results From 201 urine specimens of pathogenic bacteria culture positive rate was 98.5%(198/201), 92 cases were caused by a single pathogen(62 cases of bacterium , 30 cases of fungus), 106 cases were caused by mixed pathogens (59 cases of mixed bacteria, 5 cases of mixed fungi, 42 cases of fungal mixed bacteria and fungi). Among the 362 pathogens, 209 gram negative bacilli were found mainly as Escherichia coli.Seventy-one gram positive cocci were found mainly as Enterococcus.Eighty-two funguses were found mainly as white cocci.The resistance of pathogens isolated from patients with long-term indwelling catheter was enhanced with the increase of indwelling catheter time. The patients with long-term indwelling catheter were more resistant to the multiple drug resistance (MDRO), and some vancomycin resistant and antifungal resistant strains were isolated from some patients. Conclusions Long-term indwelling catheter associated urinary tract infections are multi-bacteria, multi-drug resistance, improve the quality of care, standard treatment, reasonable application of antibiotics has positive significance on the prevention and treatment of indwelling catheter related urinary tract infection. Key words: Urinary Catheterization; Catheters, Indwelling; Drug Resistance, Microbial

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