Abstract
This study was conducted to evaluate the accumulation and distribution of HGC (hydrophobically modified glycol chitosan) as a degradable nanoparticle in the body. To determine the movement of degradable HGC nanoparticles in the body, 20 mg/kg of lutetium-labeled HGC (Lu-HGC) with a size range from 320 to 400 nm was injected intravenously into ICR mice, and the amount of radioactivity remaining in blood and several organs was measured at various time points a period of 5 days. In the pharmacokinetics analysis using the Lu radioisotope, the free Lu was mainly distributed and accumulated in the order of kidney>liver>lung at 1 day after the injection of radioisotope. However, the Lu-HGC showed a high distribution of nanoparticles in the order of liver>spleen>kidney until 5 days. These results would provide a basic pharmacokinetics for the use of HGC as a drug carrier in drug delivery system.
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