Distributed coding in auditory thalamus and basolateral amygdala upon associative fear learning.

Abstract

Associative fear learning is a fundamental learning mechanism that is crucial for an animal's survival. The amygdala's role in fear memory formation has been studied extensively and molecular, cell type and circuit-specific learning mechanisms as well as population level encoding of threatful stimuli within the amygdala are at the core of fear learning. Nevertheless, increasing evidence suggests that fear memories are acquired, stored and modulated by a distributed neuronal network across many brain areas. Here we review recent studies that particularly re-assessed the role of auditory/lateral thalamus, which is one synapse upstream of the lateral amygdala, required for fear learning and exhibits a striking functional resemblance and plasticity pattern to downstream amygdala neurons on the single cell level, yet distinct population level coding.