Abstract
Objectives To compare right ventricular thickness (RVT) and deformation of cardiac amyloidosis (CA) and hypertrophic cardiomyopathy (HCM) patients. Methods Sixty CA (mean age 58 ± 10 years; 33 males (55%)) and sixty HCM patients (mean age 55 ± 14 years; 27 males (45%)) were retrospectively enrolled. RVT, global radical peak strain (GRPS), global longitudinal peak strain (GLPS), and global circumferential peak stain (GCPS) were analyzed. To determine the cutoff values of the RVT and RV strain parameters for distinguishing CA from HCM, the areas under the receiver operating characteristic curve (AUCs) were analyzed. Results RVT of CA patients was significantly thicker than that of HCM patients (7.8 ± 2.1 vs 5.9 ± 1.3, p < 0.001). Moreover, significantly decreased RV-GRPS (12.1 ± 6.9 vs 23.5 ± 12.1, p < 0.001), RV-GCPS (−3.4 ± 2.2 vs −5.6 ± 3.5, p < 0.001), and RV-GLPS (−4.6 ± 2.3 vs −11.1 ± 4.9, p < 0.001) were observed in CA patients compared with HCM patients. RVT and RV strain demonstrate comparable diagnostic accuracy in differentiating CA from HCM. In particular, RV-GLPS combined with RVT showed the best performance for discriminating CA from HCM (AUC = 0.92, 95% CI: 0.85 to 0.96, p = 0.0001). Conclusions Right ventricular myocardial thickness and deformation of CA patients was more severe than HCM patients. RV-GLPS combined with RVT presents an excellent diagnostic performance in distinguishing CA and HCM.
Highlights
Cardiac amyloidosis (CA) is defined by the presence of extracellular amyloid deposition within the myocardium of the whole heart, leading to biventricular wall thickening with impaired relaxation and the loss of ventricular elasticity [1]
All HCM patients enrolled in our study had nonobstructive hypertrophic cardiomyopathy, which can be divided into the following categories according to the segments of hypertrophic myocardium: (1) interventricular septal hypertrophic (n 39), (2) anterolateral wall hypertrophic (n 11), (3) posterior wall hypertrophic (n 4), and (4) diffuse left ventricle (LV) hypertrophic (n 6)
We find that the degree of right ventricle thickness (RVT) was more severe in CA patients and the RV deformation derived from the cardiovascular magnetic resonance (CMR)-tissue tracking (TT) technique showed a more significant decline in CA patients than in HCM patients
Summary
Cardiac amyloidosis (CA) is defined by the presence of extracellular amyloid deposition within the myocardium of the whole heart, leading to biventricular wall thickening with impaired relaxation and the loss of ventricular elasticity [1]. Due to the ventricular hypertrophy caused by amyloid deposition, CA has often been misdiagnosed as hypertrophic cardiomyopathy (HCM), which has main macroscopic characteristics of myocardial wall thickening and myocyte hypertrophy [2, 3]. Ough right ventricle thickness (RVT) is extensively involved in CA but less in HCM [7], the differences in RVT and RV deformation were underestimated. Us, the aims of this study were as follows: (1) to assess and compare RV thickness (RVT) and RV deformation parameters derived from the CMR-TT technique between CA and HCM patients and (2) to further identify the most valuable RV parameters for differentiating CA from HCM CMR tissue tracking (TT) technique, which could measure cardiac muscle motion and both LV and RV deformation, has emerged as more sensitive indicators than the ejection fraction (EF) [8,9,10,11,12]. us, the aims of this study were as follows: (1) to assess and compare RV thickness (RVT) and RV deformation parameters derived from the CMR-TT technique between CA and HCM patients and (2) to further identify the most valuable RV parameters for differentiating CA from HCM
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
