Abstract
Depression, a global mental illness, is worsened due to the coronavirus disease 2019 (COVID-2019) pandemic. Tricyclic antidepressants (TCAs) are efficacious for the treatment of depression, even though they have more side effects. Cyclodextrins (CDs) are powerful encapsulating agents for improving molecular stability, water solubility, and lessening the undesired effects of drugs. Because the atomic-level understanding of the β-CD–TCA inclusion complexes remains elusive, we carried out a comprehensive structural study via single-crystal X-ray diffraction and density functional theory (DFT) full-geometry optimization. Here, we focus on two complexes lining on the opposite side of the β-CD–TCA stability spectrum based on binding constants (Kas) in solution, β-CD–protriptyline (PRT) 1—most stable and β-CD–maprotiline (MPL) 2—least stable. X-ray crystallography unveiled that in the β-CD cavity, the PRT B-ring and MPL A-ring are aligned at a nearly perfect right angle against the O4 plane and primarily maintained in position by intermolecular C–H···π interactions. The increased rigidity of the tricyclic cores is arising from the PRT -CH=CH- bridge widens, and the MPL -CH2–CH2- flexure narrows the butterfly angles, facilitating the deepest and shallower insertions of PRT B-ring (1) and MPL A-ring (2) in the distorted round β-CD cavity for better complexation. This is indicated by the DFT-derived complex stabilization energies (ΔEstbs), although the complex stability orders based on Kas and ΔEstbs are different. The dispersion and the basis set superposition error (BSSE) corrections were considered to improve the DFT results. Plus, the distinctive 3D arrangements of 1 and 2 are discussed. This work provides the first crystallographic evidence of PRT and MPL stabilized in the β-CD cavity, suggesting the potential application of CDs for efficient drug delivery.
Highlights
Depression is a serious mental illness as over 300 million people worldwide suffer from depression, and about 800,000 people die from suicide each year [1]
2.4, the β-circular dichroism (CD)–Tricyclic antidepressants (TCAs) inclusion complexation investigated in the research project β-CD nomenclature is used conventionally forDFT-derived carbohydrates, i.e., atoms energies
We further evaluated to what extent the dispersion forces affect the interaction energies of eight β-CD–TCA complexes
Summary
Depression is a serious mental illness as over 300 million people worldwide suffer from depression, and about 800,000 people die from suicide each year [1]. The 2◦ and 3◦ amine TCAs share similar structures, they interact differently with neurotransmitters, having distinct. TCAs, PRTthus and and favoring maprotiline (MPL; Ludiomil) members of the 2 amine. The six widely used TCAs are the secondary amine DPM, NRT, and the tertiary amineIPM, IPM,AMT, AMT,CPM, CPM,E/Z-DXP. Like other TCAs. 6)-tricyclic core (wing-body-wing) through a vertical mirror plane bisecting the central 7-membered C-ring. The excellent inclusion ability of CDs is attributed to their amphipathic character and nanocavity size, stabilizing and interacting intermolecularly with various guest molecules [15,16]. CDs act as water solubilizers and molecular stabilizers against air, light, and heat, improving physicochemical and pharmahave made an insightful literature review on the studies of the inclusion compast three decades CDs act water solubilizers and molecular stabilizers against air, light, and heat, improving physicochemical and cological properties and bioavailability of drugs, antidepressants
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