Abstract
ObjectiveTo characterize parasomnia behaviors on arousal from NREM sleep in Parkinson’s Disease (PD) and Multiple System Atrophy (MSA).MethodsFrom 30 patients with PD, Dementia with Lewy Bodies/Dementia associated with PD, or MSA undergoing nocturnal video-polysomnography for presumed dream enactment behavior, we were able to select 2 PD and 2 MSA patients featuring NREM Parasomnia Behviors (NPBs). We identified episodes during which the subjects seemed to enact dreams or presumed dream-like mentation (NPB arousals) versus episodes with physiological movements (no-NPB arousals). A time-frequency analysis (Morlet Wavelet Transform) of the scalp EEG signals around each NPB and no- NPB arousal onset was performed, and the amplitudes of the spectral frequencies were compared between NPB and no-NPB arousals.Results19 NPBs were identified, 12 of which consisting of ‘elementary’ NPBs while 7 resembling confusional arousals. With quantitative EEG analysis, we found an amplitude reduction in the 5-6 Hz band 40 seconds before NPBs arousal as compared to no-NPB arousals at F4 and C4 derivations (p<0.01).ConclusionsMany PD and MSA patients feature various NREM sleep-related behaviors, with clinical and electrophysiological differences and similarities with arousal parasomnias in the general population.SignificanceThis study help bring to attention an overlooked phenomenon in neurodegenerative diseases.
Highlights
From 30 patients with Parkinson’s Disease (PD), Dementia with Lewy Bodies/Dementia associated with PD, or Multiple System Atrophy (MSA) undergoing nocturnal video-polysomnography for presumed dream enactment behavior, we were able to select 2 PD and 2 MSA patients featuring NREM Parasomnia Behviors (NPBs)
Patients affected with alpha-synucleinopathies (Parkinson’s Disease – PD, Dementia with Lewy Bodies – DLB/Dementia associated with Parkinson’s Disease – PDD, or Multiple System Atrophy – MSA) and their bed-partners frequently seek medical attention for “abnormal” sleep-related events that can consist of movements or behaviors of different complexity
Video-polysomnography (PSG) recordings demonstrate that these parasomnia behaviors observed in patients with synucleinopathies consist of heterogeneous behaviors, encompassing REM behavior disorder (RBD) as well as Arousal-related Motor-Behavioral Episodes (AMBEs) emerging at arousal from NREM or REM sleep [1,2,3,4]
Summary
To characterize parasomnia behaviors on arousal from NREM sleep in Parkinson’s Disease (PD) and Multiple System Atrophy (MSA).
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