Distinct Types of Antibodies in the Blood of Rabbits Carrying the Transplanted V2 Carcinoma

Abstract

Rabbits carrying the transplanted V2 carcinoma—a squamous-cell cancer derived originally from a virus-induced papilloma—regularly develop in their blood an antibody capable of neutralizing in vitro the papilloma virus (Shope) and capable also of fixing complement in mixture with it.1 Further studies have now shown that the virus-neutralizing and complement-fixing titers of sera procured from rabbits carrying the V2 carcinoma invariably parallel one another, and that the antibody responsible for both reactions can be readily absorbed from the sera upon admixture with the virus. From the findings it appears certain that the antibody is directed against the papilloma virus per se, and that it is identical with the antiviral antibody present in the blood of rabbits carrying benign virus-induced papillomas, which is in turn identical with that present in the blood of rabbits injected with purified papilloma virus.2 In further serum tests, carried out by the methods used in the serological study of the Brown-Pe...