Distinct networks coupled with parietal cortex for spatial representations inside and outside the visual field

Abstract

Our mental representation of egocentric space is influenced by the disproportionate sensory perception of the body. Previous studies have focused on the neural architecture for egocentric representations within the visual field. However, the space representation underlying the body is still unclear. To address this problem, we applied both functional Magnitude Resonance Imaging (fMRI) and Magnetoencephalography (MEG) to a spatial-memory paradigm by using a virtual environment in which human participants remembered a target location left, right, or back relative to their own body. Both experiments showed larger involvement of the frontoparietal network in representing a retrieved target on the left/right side than on the back. Conversely, the medial temporal lobe (MTL)-parietal network was more involved in retrieving a target behind the participants. The MEG data showed an earlier activation of the MTL-parietal network than that of the frontoparietal network during retrieval of a target location. These findings suggest that the parietal cortex may represent the entire space around the self-body by coordinating two distinct brain networks.