Distinct Metabolite Profile in Pemphigus Vulgaris

Abstract

Because of their high prevalence, (co)morbidity, still unsatisfactory treatment options, and imposed economic impact, chronic inflammatory skin diseases pose a major medical burden (Lamberts et al., 2019). In the past, multidimensional datasets unraveled novel pathways of disease pathogenesis and have led to the discovery of innovative therapeutic targets, exemplified by the discovery of Jak/nonreceptor tyrosine protein kinase 2 inhibitors for the treatment of psoriasis and alopecia areata (Genetic Analysis of Psoriasis Consortium & the Wellcome Trust Case Control Consortium 2 et al., 2010; Xing et al., 2014).