Abstract
Psoriatic arthritis (PsA) is defined as a heterogeneous inflammation correlating with psoriasis, usually sero-negative inflammatory arthropathy and the factor genes essential for its expression and prediction. Therefore, current study aimed to determination whether IL-1β gene expression has a role in the development of psoriatic arthritis. A total of (128) individual participated in this study, (59) with psoriasis, and (29) others with psoriatic arthritis, in addition to (40) healthy subjects. All participants were from those who attended Al-Sadr Teaching Hospital or Al-Basra teaching hospital in Basra governorate, southern Iraq, from August 2020 to February 2022. After the samples were collected, peripheral blood was isolated and total RNA was extracted to estimate the expression of the genes of interest using q RT-PCR. Our results confirmed that the expression level of IL-1β in the PsA patients was up-regulated by 22.09-fold compared with the down-regulated psoriasis patients by 2.8. Thus, we concluded that IL-1β was significant in the development of psoriatic arthritis.
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