Abstract
BackgroundTo date, studies on inflammatory breast cancer (IBC) lack comprehensive epidemiological data. We analyzed detailed prospectively collected clinical and epidemiological data from the IBC Registry at The University of Texas MD Anderson Cancer Center.MethodsPatients with IBC (n = 248) were consecutively diagnosed and prospectively enrolled between November 2006 and April 2013. All patients were newly diagnosed and at least 18 years old. Secondary IBC was excluded. Overall 160 variables were collected and evaluated including sociodemographics, anthropometrics, tobacco and alcohol consumption, reproductive variables, and family history data.ResultsMean age at diagnosis was 51.6 (±11.5 SD) years, and the majority of patients were White (77.8%). A mean BMI ≥ 25 kg/m2, irrespective of menopausal status, was observed in 80.2% of all patients, with 82.6% of African Americans being obese. Approximately 42.2% of patients were ever smokers, and 91% reported ever being pregnant. A history of breastfeeding was reported in 54% of patients, with significant differences between ethnic groups in favor of White women (P<0.0001). Other reproductive factors such as use of birth control pills & hormone replacement therapy were also more frequently associated with White women compare to other ethnic groups (P < 0.05). In the multivariate Cox proportional hazard analysis, African American or Hispanic ethnicity, not having breastfed, higher clinical stage, and TNBC subtype were associated with shorter survival.ConclusionOur data suggest that IBC is associated with distinct epidemiological profiles. This information could assist in targeting patients with specific preventive strategies based on their modifiable behavioral patterns.
Highlights
Inflammatory breast cancer (IBC) is a rare, aggressive form of breast cancer that accounts for 1–3% of breast cancers diagnosed annually in the United States [1, 2]
Our data suggest that inflammatory breast cancer (IBC) is associated with distinct epidemiological profiles
Epidemiological studies have shown that IBC presents at a younger age than non-IBC and that incidence is higher in African Americans than in Whites [2, 6,7,8]
Summary
Inflammatory breast cancer (IBC) is a rare, aggressive form of breast cancer that accounts for 1–3% of breast cancers diagnosed annually in the United States [1, 2]. Large national registries lack details required to understand the epidemiological factors associated with disease development [2,3,4,5,6,7,8,9,10,11]. To address this issue, the Morgan Welch Inflammatory Breast Cancer Research Program and Clinic at The University of Texas MD Anderson Cancer Center developed an IBC registry in 2007.
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