Abstract

Dear Editor,The RUNX gene family includes three evolutionarilyconserved genes (RUNX1, RUNX2, and RUNX3) encodingtranscription factors involved in cell lineage differentiationduring development and various forms of cancer [1].RUNX1 gene (also known as AML1 PEBP2αB or CBFA2),located in chromosome 21q22.3, is crucial for the estab-lishment of definite hematopoiesis and the generation ofhematopoietic stem cells in the embryo. RUNX1 acts as akey regulator of hematopoiesis through the regulation ofvarious hematopoietic genes [1–3].RUNX1 impairment resulting from mutation, deletion,translocation, or amplification is reported to contribute tothe pathogenesis of acute leukemias [4]. We report heredistinct clonal anomalies involving the RUNX1 geneoccurring in the course of the disease in a patient withacute myeloblastic leukemia (AML).This 51-year-old man was first seen in February 2006because of persistent rhinitis and recurrent epistaxis.Physical examination showed no adenopathy or hepatos-plenomegaly. The peripheral blood count revealed aleukocytosis of 8.6×10

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