Abstract
To understand the clinical significance of nm23 gene expression in gastric cancer patients, the Nm23-H1 protein level of fresh resected specimens from a total of 37 gastric cancer patients was measured by Western blot analysis. The elevated nm23 expression group (Nm23-H1 protein level in tumor tissue greater than the 75th percentile value of patients) was significantly associated with the histologically differentiated type ( P=0.036). This group had a higher incidence of distant (hematogeneous) metastasis ( P=0.0023) and a lower 2-year disease-free survival rate ( P=0.033) than the non-elevated group. The result was not consistent with the previous assumption that nm23 is an antimetastatic gene for gastric cancer.
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