Distance Traveled by Patients Globally to Access Radiotherapy: A Systematic Review

Abstract

This systematic review aims to investigate the global travel patterns of patients seeking radiotherapy and examines the distance traveled by patients and its impact on secondary outcomes such as travel time and survival. The findings of this review will provide crucial information on barriers to accessing radiotherapy and inform the development of patient-centered care strategies aimed at improving access to this important form of treatment. A comprehensive search of four databases was conducted from June to August 2022. Studies were included if they were observational, retrospective, or randomized/non-randomized, published between June 2000 and June 2022, and reported the distance traveled globally for the treatment of malignant or benign disease. Studies were excluded if they did not report travel distance or were not written in English. A total of 176 studies were included. Most of the studies (69.9%) were conducted in North America, with the majority (68.7%) in the United States. The treatment modalities varied with external beam radiation therapy being the most common (17.0%). The most common disease site was breast (26.7%). Of the included studies, 49 reported the mean distance traveled for radiation therapy. The shortest mean distance was reported in the United States at 4.83 miles, while the longest was reported in Iran at 276.5 miles. It was observed that patients living in countries outside the United States traveled greater distances for radiation therapy than those living within the U.S. Additional factors such as urban vs. rural residence and treatment modality were also found to impact the distance traveled for radiation therapy. Our results indicate a wide range of travel times, with approximately half of the studies reporting values greater than 1 hour, which was the case for 100% of the studies on low-income populations (n = 4). Out of 176 studies, only 15% discussed patient survival and reported conflicting results between travel distance and survival rates, regardless of treatment, disease site, or country of origin. This systematic review is the most comprehensive to date on the global travel patterns of patients seeking radiotherapy. Results show that travel distances varied, but overall, patients in the U.S. traveled shorter distances for radiation therapy than those living outside the country. Treatment center location, patient residence, and treatment modality impacted patient travel distance, but the patterns were inconsistent. These findings emphasize the importance of considering the distance traveled as a barrier to receiving radiotherapy and highlight the need for strategies to improve patient access and prioritize patient-centered care.