Abstract
Summary Distamycin A (DST-A) strongly inhibits cell proliferation of mouse lymphoma cells. The unbalanced growth of the cells observed during the DST-A caused inhibition cannot be linked to a cytotoxic effect. The DST-A effect on cell proliferation may be quenched by incubation with native DNA, but not with RNA. The two DST derivatives DST/4 and DST/5 show a high degree of inhibition of cell proliferation. DST-A inhibits the 4 different DNA-dependent DNA polymerases as well as the 3 DNA-dependent RNA polymerases to the same high extent, while inhibition of the enzymatic RNA-mediated DNA and RNA synthesis amounts to only 1.5% of it. Kinetic studies have shown that enzymatic DNA-dependent nucleic acid synthesis is inhibited in a competitive way.
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