Abstract
A five-compartment model for the liquid flow and the oxygen transfer into the liquid phase of a large-scale bioreactor is presented. The aim of the model is to predict the following reactor operating variables: 1) the overall oxygen transfer capacity of the reactor; 2) the local liquid dissolved oxygen concentrations, for estimation of bad aerated zones which can introduce negative effects for the microorganisms and as a base for reliable scaledown experiments to estimate those effects; 3) the gas-phase exhaustion.
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