Abstract
Abstract The application of the B.P. disintegration apparatus in dissolution rate studies has been examined. The dissolution profiles of some brands of chloramphenicol capsules and tolbutamide tablets have been examined at various tube speeds with and without the guided disc. For both drugs a tube speed of 20 strokes/min gave the optimum difference in dissolution rates. The effect of the guided disc depended on the disintegration time of the product tested. For poorly disintegrating products the use of the guided disc resulted in about twofold increase in dissolution whilst insignificant effect was found for products with fast dissolution rate.
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