Dissolution Profiles of Ceftizoxime Suppository

Abstract

AbstractThe in vitro dissolution rates of ceftizoxime suppository were compared using a rotating dialysis cell method, a dialysis membrane method and the JP XI rotating basket method. Only small variations in the dissolution rates were found with the rotating dialysis cell method and the rotating basket method, while the dialysis membrane method indicated rather large variation than other methods. In the rotating basket method, it was observed that a part of suppository bases came out through the wire mesh of the basket and spread over the surface of the dissolution medium. In the case of dialysis membrane method, it seemed that the large variations in dissolution rate was depending on a skill of the apparatus used.As to obtain a good results, a selection of the rotating dialysis cell method was important. In vitro dissolutions of Ceftizoxime(CZX) suppository by using the rotating dialysis cell method were very rapid and also consistent with the absorption characteristics reported previously by Motohiro a...