Abstract
Our aim was to investigate the impact of spray-drying and lyophilization techniques on the dissolution profile of acyclovir combined with a MgAl-Cl layered double hydroxide clays. Powder X-Ray Diffraction and Scanning Electron Microscopy were performed to characterize the solid state of the systems. Dissolution was performed under sink conditions in pH 6.8 buffer. Diffractograms showed that spray-dried systems had a lower degree of crystallinity compared to lyophilized ones, while photomicrographs evidenced the drug adhered to the clay surface, revealing spherical and splintered shapes for spray-dried and lyophilized systems, respectively. Clay-drug systems prepared with 2:1 M proportion via spray-drying were able to slow acyclovir release rate, compared to crystalline drug. Spray-dried systems showed a distinct kinetic release mechanism compared to lyophilized systems and crystalline acyclovir.
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