Abstract
A three-compartment apparatus was developed for dissolution studies of slightly soluble powders under sink conditions. The apparatus was designed to accommodate up to three phases to provide sink conditions. The apparatus could accommodate a barrier in the dissolution medium to prevent floating powders from entering and dissolving directly into the sink phase. Dissolution studies were conducted with several particle size grades of salicylic acid under nonsink as well as sink conditions. Effects of the rate of agitation and methods of introducing samples (dry or wetted suspensions) were also investigated. The data indicated that under diffusion-controlled rate of agitation, using the appropriate placement of propellers, it was possible to establish a rank order for in vitro dissolution times of different particle size salicylic acid powders.
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